Effect of oats and/or lovastatin on lipid profile in dyslipidemic patients of the Tunjuelito hospital, Bogota 2008-2009
Efecto de la avena y/o lovastatina sobre el perfil lipídico en pacientes dislipidémicos del hospital de Tunjuelito, Bogotá 2008-2009
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Abstract
It has been postulated that diets rich in fiber are useful to reduce cardiovascular risk. Among the most commonly used lipid-lowering drugs are statins, fibrates, and in 1997 the FDA approved oats This research aimed to determine the effect of oats and lovastatin on lipid profile of dyslipidemic patients. The patient sample consisted of a total of 84 with dyslipidemia Tunjuelito hospital in Bogota. Were randomized and drug administration was conducted in randomly. Group 1 was administered Oats (A), 29 cases (34.5%). Lovastatin+Avena Group 2 (A + L), 22 cases (26.2%) and Group 3 Lovastatin (L), 33 cases (39.3%). They were followed for 12 weeks. The data were processed using SPSS. BMI showed no differences in group 1, being more significant in group 2 than in group 3. Waist circumference evidenced significant differences in the three groups. Cholesterol showed significant differences between group 1 and 3. Triglycerides showed significance in groups 2 and 3. This study provides evidence that dyslipidemic patients benefit by adding a natural product like oatmeal on abdominal circumference parameters and cholesterol.
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AIT-OUFELLA, H.; TALEB, S.; MALLAT, Z.; TEDGUI, A. 2011. Recent advances on the role of cytokines in atherosclerosis. Arterioscl. Thromb. Vas. Biol. 31(5):969-979.
BEHALL, K.M.; SCHOLFIELD, D.J.; HALLFRISCH, J. 2004. Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women. Am. J. Clin. Nutr. 80(5):1185-1193.
BERGLUND, L.; BRUNZELL, J.D.; GOLDBERG, A.C.; GOLDBERG, I.J.; SACKS, F.; MURAD, M.H.; STALENHOEF, A.F. 2012. Evaluation and treatment of hypertriglyceridemia: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 97(9):2969-2989.
CASTAÑO VALENCIA, O. 2001. Factores de riesgo en la ciudad de Manizales. Archivos de Medicina. Universidad de Manizales. 1(3):17-22.
DAVY, B.M.; DAVY, K.P.; HO, R.C.; BESKE, S.D.; DAVRATH, L.R.; MELBY, C.L. 2002. High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men. Am. J. Clin. Nutr. 76(2):351-358.
JENKINS, D.J.A.; KENDALL, C.W.C.; MARCHIE, A.; FAULKNER, D.A.; WONG, J.M.W.; DE SOUZA, R.; EMAM, A.; PARKER, T.L.; VIDGEN, E.; TRAUTWEIN, E.A.; LAPSLEY, K.G.; JOSSE, R.G.; LEITER, L.A.; SINGER, W.; CONNELLY, P.W. 2005. Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants. Am. J. Clin. Nutr. 81(2):380-387.
JONES, P.J.; RAEINI-SARJAZ, M.; JENKINS, D.J.; KENDALL, C.W.; VIDGEN, E.; TRAUTWEIN, E.A.; LAPSLEY, K.G.; MARCHIE, A.; CUNNANE, S.C.; CONNELLY, P.W. 2005. Effects of a diet high in plant sterols, vegetable proteins, and viscous fibers (dietary portfolio) on circulating sterol levels and red cell fragility in hypercholesterolemic subjects. Lipids. 40(2):169-174.
JULA, A.; MARNIEMI, J.A.; HUUPPONEN, R.; VIRTANEN, A.; RASTAS, M.; RÖNNEMAA, T. 2002. Effects of diet and simvastatin on serum lipids, insulin and antioxidants in hypercholesterolemic men:a randomized controlled trial. JAMA. 287(5):598-605.
KARL, J.P.; SALTZMAN, E. 2012. The role of whole grains in body weight regulation. Adv. Nutr. 3(5):697-707.
KATZ, D.L.; EVANS, M.A.; CHAN, W.; NAWAZ, H.; COMERFORD, B.P.; HOXLEY, M.L.; NJIKE, V.Y.; SARREL, P.M. 2004. Oats, antioxidants and endothelial function in overweight, dyslipidemic adults. J. Am. Coll. Nutr. 23(5):397-403.
KERCHHOFFS, D.; HORNSTRA, G.; MENSINK, R.P. 2003. Cholesterol-lowering effect of glucan from oat bran in mildly hypercholesterolemic subjects may decrease when glucan is incorporated into bread and cookies. Am. J. Clin. Nutr. 78:221-227.
LONGYHORE, D.S.; STOCKTON, C.M.; THOMAS, M.R. 2009. Profile changes associated with changing available formulary statins: removing higher potency agent. Am. J. Manag. Care. 15(7):409-414.
MAKI, K.C.; DAVIDSON, M.H.; WITCHGER, M.S.; DICKLIN, M.R.; SUBBAIAH, P.V. 2007. Effects of highfiber oat and wheat cereals on postprandial glucose and lipid responses in healthy men. Int. J. Vitam Nutr. Res. 77(5):347-356.
ONATRA, W.; GARCÍA, C.; GAMBOA, C.; SÁNCHEZ, J.; CASTRO, J. 2006. Prevalencia del síndrome metabólico en mujeres posmenopausicas en dos centros clínicos de Bogotá. Rev. U.D.C.A Act. & Div. Cient. 9:43-53.
POPPIT, S.D. 2007. Soluble fibre oat and barley -glucan enriched products: can we predict cholesterol-lowering effects? Br. J. Nutr. 97(6):1049-1050.
PRIETO ALBINO, L.; ARROYO DÍEZ, J.; VADILLO MACHOTA, J.M.; MATEOS MONETERO, C.; GALAN REBOLLO, A. 1998. Prevalencia de hiperlipidemia en niños y adolescentes de la provincia de Cáceres. Rev. Española Salud Publ. 72:343-355.
ROSANO, M.; VITALE, C.; TULLI, A. 2007. Manejo del riesgo cardiovascular en mujeres postmenopausicas. Rev. Col. Menopausia 13(1):25-28.
RUIZ, R.M.; MORILLO, L.E. 2004. Epidemiologia Clínica: Investigación clínica aplicada. Ed. Panam. Bogota- Madrid-Sao Paulo. p.181-194.
RULLÁN BONILLAS, A. 2002. La avena y sus efectos hipocolesterolemicos. Nutr. Clin. 5(3):139-146.
SALTZMAN, E.; MORIGUTI, J.C.; DAS, S.K.; CORRALES, A.; FUSS, P.; GREENBERG, A.S.; ROBERTS, S.B. 2001a. Effects of a cereal rich in soluble fiber on body composition and dietary compliance during consumption of a hypocaloric diet. J. Am. Coll. Nutr. 20:50-57.
SALTZMAN, E.; DAS, S.K.; LICHTENSTEIN, A.H.; DALLAL, G.E.; CORRALES, A.; SCHAEFER, E.J.; GREENBERG, A.S.; ROBERTS, S.B. 2001b. An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women. J. Nutr. 131(5):1465-1470.
SHINNICK, F.L.; INK, S.L.; MARLETT, J.A. 1990. Dose response to a dietary oat bran fraction in cholesterol fed rats. J. Nutri. 120(6):561-568.
SWAIN, J.F.; ROUSE, I.L.; CURLEY, C.B.; SACKS, F.M. 1990. Comparison of the effects of oat bran and lowfiber wheat on serum lipoprotein levels and blood pressure. New Engl. J. Med. 322(3):147-152.
TOBERT, J.A. 2003. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug Discov. 2(7):517-526.
VAIDYA, D.; SZKLO, M.; CUSHMAN, M.; HOLVOET, P.; POLAK, J.; BAHRAMI, H.; JENNY, N.S.; OUYANG, P. 2011. Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosis. Eur. J. Clin. Nutr. 65(7):818-825.
VILLARREAL, E.; FORERO, Y.; POVEDA, E.; BARACALDO, C.; LÓPEZ E. 2008. Marcadores de riesgo cardiovascular en escolares de cinco departamentos de la región oriental en Colombia. Biomedica. 28(1):38-49.
ZHOU, Q.; LIAO, J.K. 2010. Pleiotropic effects of statins: Basic research and clinical perspectives. Circ. J. 74(5):818-826.
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