Espectrometría de movilidad iónica: historia, características y aplicaciones

Ion mobility spectrometry: history, characteristics and applications

Contenido principal del artículo

Roberto Fernández Maestre

Resumen

La espectrometría de movilidad iónica (IMS) es una técnica analítica que separa iones en fase gaseosa. Los iones son separados a presión atmosférica bajo la influencia de un campo eléctrico de acuerdo a su tamaño y forma. IMS es la mejor opción para detectar narcóticos, agentes químicos y biológicos de guerra, y explosivos en aeropuertos y aduanas. IMS puede detectar casi cualquier cosa que pueda ser ionizada y se ha aplicado al análisis de elementos ligeros como el helio, mezclas más complejas como proteomas, metabolomas y organismos completos, tales como bacterias, separaciones quirales, y la determinación de estructuras. Aunque desde el año 2000 se han presentado aproximadamente cincuenta revisiones de la IMS, la presente es probablemente la única en evaluar este tema de manera general desde esa fecha y es probablemente la primera en publicarse en una revista latinoamericana.

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ALBRITTON, D.L.; MILLER, T.M.; MARTIN, D.W.; MCDANIEL, E.W. 1968. Mobilities of mass-identified H3+ and H+ ions in hydrogen. Phys. Rev. 171(1):94-102.

ASBURY, G.R.; KLASMEIER, J.; HILL, Jr. H.H. 2000. Analysis of explosives using electrospray ionization/ ion mobility spectrometry (ESI/IMS). Talanta. 50(6):1291-1298.

ASBURY, G.R.; HILL, Jr. H.H. 2000. Using different drift gases to change separation factors (a) in ion mobility spectrometry. Anal. Chem. 72(3):580-584.

BACON, A.T.; GETZ, R.; REATEGUI, J. 1991. Ion-mobility spectrometry tackles tough process monitoring. J. Chem. Eng. Program. 87(6):61-64.

BAIM, M.A.; HILL, Jr. H.H. 1982. Tunable selective detection for capillary gas chromatography by ion mobility monitoring. Anal. Chem. 54(1):38-43.

BAIM, M.A.; EATHERTON, R.L.; HILL, Jr H.H. 1983. Ion mobility detector for gas chromatography with a direct photoionization source. Anal. Chem. 55(11):1761-1766.

BERANT, Z.; KARPAS, Z. 1989. Mass-mobility correlation of ions in view of new mobility data. J. Am. Chem. Soc. 111(11):3819-3824.

BESSA, V.; DARWICHE, K.; TESCHLER, H.; SOMMERWERCK, U.; RABIS, T.; BAUMBACH, J.I.; FREITAG, L. 2011. Detection of volatile organic compounds (VOCs) in exhaled breath of patients with chronic obstructive pulmonary disease (COPD) by ion mobility spectrometry. Int. J. Ion Mob. Spectrom. 14(1):7-13.

BLUHM, B.K.; GILLIG, K.J.; RUSSELL, D.H. 2000. Development of a Fourier-transform ion cyclotron resonance mass spectrometer-ion mobility spectrometer. Rev. Sci. Instrum. 71(11):4078-4086.

BOCOS-BINTINTAN, V.; MOLL, V.H.; FLANAGAN, R.J.; THOMAS, C.L.P. 2010. Rapid determination of alcohols in human saliva by gas chromatography differential mobility spectrometry following selective membrane extraction. Int. J. Ion Mob. Spectrom. 13(2):55-63.

BOGGIO, N.G.; PIERPAULI, K.; RINALDI, C.A.; LAMAGNA, A. 2011. Detection of volatile organic compound with an ion mobility spectrometry cell type device with a corona discharge ionization source. Sensor Lett. 9(2):866-868.

BOLLAN, H.R.; STONE, J.A.; BROKENSHIRE, J.L.; RODRIGUEZ, M.R.; EICEMAN, G.A. 2007. Mobility resolution and mass analysis of ions from ammonia and hydrazine complexes with ketones formed in air at ambient pressure. J. Am. Soc. Mass Spectrom. 18(5):940-951.

BOTA, G.M.; HARRINGTON, P.B. 2006. Direct detection of trimethylamine in meat food products using ion mobility spectrometry. Talanta 68(3):629-635.

BUNKOWSKI, A.; MADDULA, S.; DAVIES, A.N.; WESTHOFF, M.;LITTERST, P.; BÖDEKER, B.; BAUMBACH, J.I. 2010. One year time series of investigations of analytes within human breath using ion mobility spectrometry. Int. J. Ion Mobil. Spectrom. 13(3-4):141-148.

CARSTENS, E.T.H.; HIRN, A.; QUINTEL, M.; NOLTE, J.; JÜNGER, M.; PERL, T.; VAUTZ, W. 2010. Online determination of serum propofol concentrations by expired air analysis. Int. J. Ion Mob. Spectrom. 13(1):37-40.

CLOWERS, B.H.; HILL, H.H. 2005. Mass analysis of mobility-selected ion populations using dual gate, ion mobility, quadrupole ion trap mass spectrometry. Anal. Chem. 77(18):5877-5885.

COHEN, M.J.; KARASEK, F.W. 1970. Plasma chromatography - a new dimension for gas chromatography and mass spectrometry. J. Chromatogr. Sci. 8(6):330-337.

DE HOFFMANN, E.; STROOBANT, V. 2001. Mass spectrometry: principles and applications. 3rd edition. John Wiley and Sons. 493p.

DWIVEDI, P.; WU, C.; MATZ, L.M.; CLOWERS, B.H.; SIEMS, W.F.; HILL, Jr. H.H. 2006. Chiral separation by ion mobility spectrometry. Anal. Chem. 78(24):8200- 8206.

DWIVEDI, P.; PUZON, G.; TAM, M.; LANGLAIS, D.; JACKSON, S.; KAPLAN, K.; SIEMS, W.F.; HILL, H.H. 2010. Metabolic profiling of Escherichia coli by ion mobility-mass spectrometry with MALDI ion source. J. Mass Spectrom. 45(12):1383-1393.

DWORZANSKI, J.P.; TRIPATHI, A.; SNYDER, A.P.; MASWDEH, W.M.; WICK, C.H. 2005. Novel biomarkers for Gram-type differentiation of bacteria by pyrolysis-gas chromatography-mass spectrometry. J. Anal. Appl. Pyrolysis 73(1):29-38.

EATHERTON, R.L.; MORRISSEY, M.A.; HILL, H.H. 1988. Comparison of ion mobility constants of selected drugs after capillary gas chromatography and capillary supercritical fluid chromatography. Anal. Chem. 60(20):2240-2243.

EICEMAN, G.A.; SALAZAR, M.R.; RODRIGUEZ, M.R.; LIMERO, T.F.; BECK, S.W.; CROSS, J.H.; YOUNG, R.; JAMES, J.T. 1993. Ion mobility spectrometry of hydrazine, monomethylhydrazine, and ammonia in air with 5-nonanone reagent gas. Anal. Chem. 65(13):1696-1702.

EICEMAN, G.A.; WANG, Y.F.; GARCIA-GONZALEZ, L.; HARDEN, C.S.; SHOFF, D.B. 1995. Enhanced selectivity in ion mobility spectrometry analysis of complex mixtures by alternate reagent gas chemistry. Anal. Chim. Acta 306(1):21-33.

EICEMAN, G.A.; NAZAROV, E.G.; STONE, J.A. 2003. Chemical standards in ion mobility spectrometry. Anal. Chim. Acta 493(2):185-194.

EICEMAN, G.A.; KARPAS, Z. 2005. Ion mobility spectrometry. 2nd edition. Boca Raton: FL.CRC Press. 350p.

ELLIS, H.W.; PAI, R.Y.; GATLAND, I.R.; MCDANIEL, E.W.; WERNLUND, R.; COHEN, M.J. 1976. Ion identity and transport properties in CO2 over a wide pressure range. J. Chem. Phys. 64(10):3935-3941.

EXCELLIMS CORPORATION. 2011. Available in internet in: http://www.excellims.com Accessed on 12/2/2011.

FERNÁNDEZ-MAESTRE, R.; HILL Jr., H.H. 2009. Ion mobility spectrometry for the rapid analysis of over- the-counter drugs and beverages. Int. J. Ion Mob. Spectrom. 12(1):3-14.

FERNÁNDEZ-MAESTRE, R.; HARDEN, C.S.; EWING, R.G.; CRAWFORD, C.L.; HILL Jr., H.H. 2010a. Chemical standards in ion mobility spectrometry. Analyst 135(6):1433-1442.

FERNÁNDEZ-MAESTRE, R.; WU, C.; HILL, H.H. 2010b. Using a buffer gas modifier to change separation selectivity in ion mobility spectrometry. Int. J. Mass Spectrom. 298(1-3):2-9.

FERNÁNDEZ-MAESTRE, R.; WU, C.; HILL Jr., H.H. 2012. Buffer gas modifiers effect resolution in ion mobility spectrometry through selective ion-molecule clustering reactions. Rap. Comm. Mass Spectrom. Accepted.

FINTHAMMER, M.; BEIERLE, C.; FISSELER, J.; KERN-ISBERNER, G.; BAUMBACH, J.I. 2010. Using probabilistic relational learning to support bronchial carcinoma diagnosis based on ion mobility spectrometry. Int. J. Ion Mob. Spectrom. 13(2):83- 93.

GAN, T.H.; CORINO, G.T. 2000. Selective detection of alkanolamine vapors by ion mobility spectrometry with ketone reagent gases. Anal. Chem. 72(4):807- 815.

GUHARAY, S.K.; DWIVEDI, P.; HILL, H.H. 2008. Ion mobility spectrometry: ion source development and applications in physical and biological sciences. IEEE T. Plasma Sci. 36(4):1458-1470.

GUNZER, F.; ULRICH, A.; BAETHER, W. 2010. A novel non-radioactive electron source for ion mobility spectrometry. Int. J. Ion Mob. Spectrom. 13(1):9-16.

HALLEN, R.W.; SHUMATE, C.B.; SIEMS, W.F.; TSUDA, T.; HILL, H.H. 1989. Preliminary investigation of ion mobility spectrometry after capillary electrophoretic introduction. J. Chromatogr. A. 480:233-245.

HILL, Jr., H.H.; SIMPSON, G. 1997. Capabilities and limitations of ion mobility spectrometry for field screening applications. J. Field Anal. Chem. Technol. 1(3):119-134.

JOHNSON, P.V.; BEEGLE, L.W.; KIM, H.I.; EICEMAN, G.A.; KANIK, I. 2007. Ion mobility spectrometry in space exploration. Int. J. Mass Spectrom. 262(1- 2):1-15.

KANU, A.B.; HILL Jr., H.H. 2008. Ion mobility spectrometry detection for gas chromatography. J. Chromatogr. A. 1177(1):12-27.

KANU, A.B.; DWIVEDI, P.; TAM, M.; MATZ, L.; HILL, H.H. Jr. 2008. Ion mobility-mass spectrometry. J. Mass Spectrom. 43(1):1-22.

KARASEK, F.W 1970. Drift-mass spectrometer. Res. Develop. 21(12):25 (cited in KARASEK F.W 1972. Trace analysis and fundamental studies by plasma chromatography. Int. J. Environ. Anal. Chem. 21(12):157-166.

KIM, S.H.; KARASEK, F.W.; ROKUSHIKA, S. 1978. Plasma chromatography with ammonium reactant ions. Anal. Chem. 50(1):152-155.

KOJIRO, D.R.; COHEN, M.J.; STIMAC, R.M.; WERNLUND, R.F.; HUMPHRY, D.E.; NORISHIGE, T. 1991. Determination of C1-C4 alkanes by ion mobility spectrometry. Anal. Chem. 63(20):2295- 2300.

LANGEVIN, P. 1903. L'ionization des gaz. Ann. Chim. Phys. 28:289-384.

LAWRENCE, A.H.; NEUDORFL, P. 1988. Detection of ethylene glycol dinitrate vapors by ion mobility spectrometry using chloride reagent ions. Anal. Chem. 60(2):104-109.

LAWRENCE, A.H.; BARBOUR, R.J.; SUTCLIFFE, R. 1991. Identification of wood species by ion mobility spectrometry. Anal. Chem. 63(13):1217-1221.

LEE, D-S.; WU, C.; HILL Jr., H.H. 1998. Detection of carbohydrates by electrospray ionization - ion mobility spectrometry following microbore high- performance liquid chromatography. J. Chromatogr. A. 822(1):1-9.

LOVELOCK, J.E.; WASILEWSKA, E.M. 1949. An ionisation anemometer. J. Sci. Instr. 26(11):367-370.

LUBMAN, D.M.; KRONICK, M.N. 1982a. Plasma chromatography with laser-produced ions. Anal. Chem. 54(9):1546-1551.

LUBMAN, D.M.; KRONICK, M.N. 1982b. Discrimination of isomers of xylene by resonance enhanced two- photon ionization. Anal. Chem. 54(13):2289-2291.

MÁRQUEZ-SILLERO, I.; AGUILERA-HERRADOR, E.; CÁRDENAS; S.; VALCÁRCEL, M. 2011.Ion-mobility spectrometry for environmental analysis. TrAC Trends Anal. Chem. 30(5):677.

MASON, E.A.; SCHAMP, Jr. H.W. 1958. Mobility of gaseous ions in weak electric fields. Ann. Phys. 4(3):233-270.

McDANIEL, E.W.; MARTIN, D.W.; BARNES, W.S. 1962. Drift-tube mass spectrometer for studies of low- energy ion-molecule reactions. Rev. Sci. Instr. 33(1):2-7.

McDANIEL, E.W. 1964. Collisional phenomena in ionized gases, New York: Wiley. 242p.

McLEAN, J.A.; RUOTOLO, B.T.; GILLIG, K.J.; RUSSELL, D.H. 2005. Ion mobility-mass spectrometry: a new paradigm for proteomics. Int. J. Mass Spectrom. 240(3):301-315.

McMINN, D.G.; KINZER, J.A.; SHUMATE, C.B.; SIEMS, W.F.; HILL Jr., H.H. 1990. Ion mobility detection following liquid chromatographic separation. J. Microcolumn Sep. 2(4):188-192.

MENG, Q.; KARPAS, Z.; EICEMAN, G.A. 1995. Monitoring indoor ambient atmospheres for volatile organic compounds using an ion mobility analyzer array with selective chemical ionization. Int. J. Environ. Anal. Chem. 61(2):81-94.

MORRISSEY, M.A.; WIDMER, H.M. 1991. Ion-mobility spectrometry as a detection method for packed- column supercritical fluid chromatography. J. Chromatogr. 552:551-561.

MYUNG, S.; WISEMAN, J.M.; VALENTINE, S.J.; TAKATS, Z.; COOKS, R.G.; CLEMMER, D.E. 2006. Coupling desorption electrospray ionization with ion mobility / mass spectrometry for analysis of protein structure: evidence for desorption of folded and denatured states. J. Phys. Chem. B 10 (10):5045-5051.

PROCTOR; C.J.; TODD, J.F.J. 1984. Alternative reagent ions for plasma chromatography. Anal. Chem. 56(11):1794-1797.

PUTON, J.; NOUSIAINEN, M.; SILLANPAA, M. 2008. Ion mobility spectrometers with doped gases. Talanta 76(5):978-987.

REARDEN, P.; HARRINGTON, P.B. 2005. Rapid screening of precursor and degradation products of chemical warfare agents in soil by solid-phase microextraction ion mobility spectrometry (SPME-IMS). Anal. Chim. Acta 545(1):13-20.

REVERCOMB, H.E.; MASON, E.A. 1975. Theory of plasma chromatography/ gaseous electrophoresis. Anal. Chem. Rev. 47(7):970-983.

ROKUSHIKA, S.; HATANO, H.; HILL Jr., H.H. 1987. Ion mobility spectrometry after supercritical fluid chromatography. Anal. Chem. 59(1):8-12.

RUTHERFORD, E. 1897. The velocity and rate of recombination of the ions of gases exposed to Rontgen radiation. Phil. Mag. 44(270):422-440.

RUTHERFORD, E. 1899. Uranium radiation and the electrical conduction produced by it. Phil. Mag. 47(284):109-163.

SABO, M.; MATEJCIK, S. 2011. Ion mobility spectrometry for monitoring high-purity oxygen. Anal. Chem. 83(6):1985-1989.

SHEIBANIA, A.; TABRIZCHI, M.; GHAZIASKAR, H.S. 2011. Determination of methadone in human hair by headspace extraction and ion mobility spectrometry. Anal. Lett. 44(4):667-675.

SHUMATE, C.B.; ST. LOUIS, R.H.; HILL Jr., H.H. 1986. Table of reduced mobility values from ambient pressure ion mobility spectrometry. J. Chromatogr. 373:141-173.

SHUPP, A.M.; RODIER, D.; ROWLEY, S. 2007. Monitoring airborne molecular contamination: a quantitative and qualitative comparison of real-time and grab- sampling techniques. Proc. SPIE, the International Society for Optical Engineering 6518, 65183Z. doi:10.1117/12.707776.

SNYDER, A.P.; SHOFF, D.B.; EICEMAN, G.A.; BLYTH, D.A.; PARSONS, J.A. 1991. Detection of bacteria by ion mobility spectrometry. Anal. Chem. 63(5):526- 529.

SPANGLER, G.E.; CARRICO, J.P. 1983. Membrane inlet for ion mobility spectrometry. Int. J. Mass Spectrom. Ion Phys. 52(2-3):267-287.

SPANGLER, G.E.; CAMPBELL, D.N.; CARRICO, J.P. 1985. Recent Advances in ion mobility spectrometry for explosives vapor detection. J. Test Eval. 13(3):234- 241.

ST. LOUIS, R.H.; SIEMS, W.F.; HILL Jr., H.H. 1989. Evaluation of direct axial sample introduction for ion mobility detection after capillary gas chromatography. J. Chromatogr. 479(2):221-231.

ST. LOUIS, R.H.; HILL, Jr.; H.H.; EICEMAN, G.A. 1990. Ion mobility spectrometry in analytical chemistry. CRC Cr. Rev. Anal. Chem. 21(5):321-355.

TABRIZCHI, M.; ROUHOLAHNEJAD, F. 2004. Corona discharge ion mobility spectrometry at reduced pressures. Rev. Sci. Instr. 75(11):4656-4662.

TIEBE, C.; HÜBERT, T.; KOCH, B.; RITTER, U.; STEPHAN, I. 2010. Investigation of gaseous metabolites from moulds by ion mobility spectrometry (IMS) and gas chromatography-mass spectrometry (GC-MS). Int. J. Ion Mob. Spectrom. 13(1):17-24.

UGAROV, M.V.; EGAN, T.; KHABASHESKU, D.V.; SCHULTZ, J.A.; PENG, H.; KHABASHESKU, V.N.; FURUTANI, H.; PRATHER, K.S.; WANG, J.H.W.; JACKSON, S.N.; WOODS, A.S. 2004. MALDI matrices for biomolecular analysis based on functionalized carbon nanomaterials. Anal. Chem. 76(22):6734-6742.

VALENTINE, S.J.; COUNTERMAN, A.E.; HOAGLUND, C.S.; REILLY, J.P.; CLEMMER, D.E. 1998. Gas-phase separations of protease digests. J. Am. Soc. Mass Spectrom. 9(11):1213-1216.

VAUTZ, W.; BAUMBACH, J.I.; UHDE, E. 2006. Detection of emissions from surfaces using ion mobility spectrometry. Anal. BioAnal. Chem. 384(4):980-986.

WEIS, P. 2005. Structure determination of gaseous metal and semi-metal cluster ions by ion mobility spectrometry. Int. J. Mass Spectrom. 245(1-3):1-13.

WU, C.; SIEMS, W.F.; HILL Jr., H.H.; HANNAN, R.M. 1998. Analytical determination of nicotine in tobacco by supercritical fluid chromatography-ion mobility detection. J. Chromatogr. A. 811(1-2):157-161.

WU, C.; SIEMS, W.F.; HILL Jr., H.H. 2000. Secondary electrospray ionization ion mobility spectrometry/ mass spectrometry of illicit drugs. Anal. Chem. 72(2):396-403.

WYTTENBACH T.; VON HELDEN G.; BOWERS M.T. 1996. Gas-phase conformation of biological molecules:? bradykinin. J. Am. Chem. Soc. 118(35):8355-8364

YUAN, A.; ALIAGA-ROSSEL, R.; CHOI, P.; GILLES, J.P. 2005. Development of a short pulsed corona discharge ionization source for ion mobility spectrometry. Rev. Sci. Instr. 76(8):085105-085105-6.

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